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A modular approach to prepare enantioenriched cyclobutanes: synthesis of (+)-rumphellaone A.

Jordan C BeckCaitlin R LackerLauren M ChapmanSarah E Reisman
Published in: Chemical science (2018)
A modular synthesis of enantioenriched polyfunctionalized cyclobutanes was developed that features an 8-aminoquinolinamide directed C-H arylation reaction. The C-H arylation products were derivatized through subsequent decarboxylative coupling processes. This synthetic strategy enabled a 9-step enantioselective total synthesis of the antiproliferative meroterpenoid (+)-rumphellaone A.
Keyphrases
  • room temperature
  • electron transfer