X-ray-triggered NO-released Bi-SNO nanoparticles: all-in-one nano-radiosensitizer with photothermal/gas therapy for enhanced radiotherapy.
Fangmei ZhangShikai LiuNa ZhangYe KuangWenting LiShili GaiFei HeAanisa GulzarPiaoping YangPublished in: Nanoscale (2021)
Hypoxia in tumor cells is regarded as the most crucial cause of clinical drug resistance and radio-resistance; thus, relieving hypoxia of tumor cells is the key to enhancing the efficacy of anticancer therapy. As a gas signal molecule of vasodilatation factors, nitric oxide (NO) can relieve the hypoxia status of tumor cells, thereby, enhancing the sensitivity of tumor cells to radiotherapy. However, considering complications of vascular activity, the level of NO required for radiotherapy sensitization cannot be obtained in vivo. In view of this, we design and fabricate a multifunctional bismuth-based nanotheranostic agent, which is functionalized with S-nitrosothiol and termed Bi-SNO NPs. X-rays break down the S-N bond and simultaneously trigger large amount of NO-releasing (over 60 μM). Moreover, the as-prepared Bi-SNO NPs not only possess the capability of absorbing and converting 808 nm NIR photons into heat for photothermal therapy, but also have the ability to increase X-ray absorption and CT imaging sensitivity. In addition, the collaborative radio-, photothermal-, and gas-therapy of Bi-SNO in vivo was further investigated and remarkable synergistic tumor inhibition was realized. Finally, no obvious toxicity of Bi-SNO NPs was observed in the treated mice within 14 days. Therefore, the Bi-SNO developed in this work is an effective nano-agent for cancer theranostics with well-controlled morphology and uniform size (36 nm), which could serve as a versatile CT imaging-guided combined radio-, photothermal- and gas-therapy nanocomposite with negligible side effects.
Keyphrases
- room temperature
- reduced graphene oxide
- photodynamic therapy
- high resolution
- cancer therapy
- perovskite solar cells
- dual energy
- drug delivery
- early stage
- nitric oxide
- drug release
- ionic liquid
- computed tomography
- gold nanoparticles
- radiation therapy
- fluorescence imaging
- endothelial cells
- locally advanced
- radiation induced
- image quality
- oxide nanoparticles
- stem cells
- papillary thyroid
- young adults
- squamous cell carcinoma
- carbon dioxide
- mass spectrometry
- insulin resistance
- mesenchymal stem cells
- rectal cancer
- metabolic syndrome
- bone marrow
- adipose tissue
- magnetic resonance
- cell therapy
- high speed
- atomic force microscopy
- wild type
- pet ct