Subclonal somatic copy number alterations emerge and dominate in recurrent osteosarcoma.
Michael D KinnamanSimone ZaccariaAlvin P Makohon-MooreBrian J ArnoldMax Fine LevineGunes GundemJuan Esteban Arango OssaDominik GłodzikM Irene Rodríguez-SánchezNancy BouvierShanita LiEmily StockfischMarisa DuniganCassidy CobbsUmesh BhanotDaoqi YouKatelyn MullenJerry P MelchorMichael V OrtizTara J O'DonohueEmily K SlotkinLeonard H WexlerFilemon Dela CruzMeera R HameedJulia L Glade BenderWilliam D TapPaul A MeyersElli PapaemmanuilAndrew L KungChristine A Iacobuzio-DonahuePublished in: bioRxiv : the preprint server for biology (2023)
gain/amplification being the defining characteristic in our cohort. Selective pressure from neoadjuvant chemotherapy revealed this clone at the time of primary resection, highlighting that genomic profiling at this time may identify clones that are selected for, or determine innate resistance to primary chemotherapy.