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Cross-protein transfer learning substantially improves disease variant prediction.

Milind JagotaChengzhong YeCarlos AlborsRuchir RastogiAntoine KoehlNilah IoannidisYun S Song
Published in: Genome biology (2023)
Our results demonstrate the utility of mutational scanning data for learning properties of variants that transfer to unseen proteins.
Keyphrases
  • copy number
  • electronic health record
  • high resolution
  • big data
  • amino acid
  • electron transfer
  • machine learning
  • binding protein
  • dna methylation
  • genome wide