The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team Review.
Luca TagliaferriValentina LancellottaCalogero CasàSimona Maria FragomeniCostanza Maria DonatiStefano GentileschiAnna Amelia CarettoGiacomo CorradoBenedetta GuiGiuseppe Ferdinando CollocaMaria Antonietta GambacortaAlessio Giuseppe MorgantiGiorgia GarganeseGabriella MacchiaPublished in: Cancers (2021)
Locally advanced vulvar cancer (LAVC) is a challenging disease, requiring multidisciplinary management. The aim of this review is to propose an integrated clinical approach including radiotherapy (RT) in the multidisciplinary management of LAVC to customize the treatment. A review of the literature was conducted on PubMed, Scopus, and Cochrane library to acquire all relevant studies on RT in LAVC. Based on the available evidence, RT, with or without concurrent chemotherapy, has a relevant role as adjuvant and exclusive treatment or in the neoadjuvant setting. However, multicentric prospective trials are needed to define the best treatment options based on tumor and patient characteristics. A multidisciplinary and multidimensional assessment can also be useful to identify the most suitable approach, considering patients' age and comorbidities, in view of a better treatment personalization.
Keyphrases
- locally advanced
- rectal cancer
- neoadjuvant chemotherapy
- squamous cell carcinoma
- radiation therapy
- phase ii study
- early stage
- quality improvement
- end stage renal disease
- papillary thyroid
- ejection fraction
- chronic kidney disease
- newly diagnosed
- sentinel lymph node
- squamous cell
- combination therapy
- peritoneal dialysis
- palliative care
- open label
- study protocol
- childhood cancer