Peroxoniobium inhibits leukemia cell growth.
Elene C Pereira-MaiaIvina P SouzaKelen J R C NunesAlexandre A CastroTeodorico Castro RamalhoFernando StefflerHélio Anderson DuarteAna PacheliPoliana ChagasLuiz C A OliveiraPublished in: RSC advances (2018)
A new class of polyoxoniobate complex has been synthesized and characterized as a novel anticancer agent for photodynamic therapy. The complex inhibits the growth of chronic myelogenous leukemia cells with an IC 50 value of 30 μM, in the dark. However, upon exposure to light (365 nm) there is a fivefold increase in the cytotoxic activity. Light radiation activate the complex with the formation of radical species capable of interacting with DNA according to our experimental and theoretical data.