Age-related changes in plasma biomarkers and their association with mortality in COVID-19.
Erik H A MichelsBrent AppelmanJustin de BrabanderRombout B E van AmstelOsoul ChouchaneChristine C A van LingeAlex R SchuurmanTom D Y ReijndersTitia A L SulzerAugustijn M KlarenbeekRenée A Doumanull nullLieuwe D J BosW Joost WiersingaHessel Peters SengersTom van der PollPublished in: The European respiratory journal (2023)
Ageing is associated with a strong and broad modification of the host response to COVID-19, and specific immune changes likely contribute to increased mortality in older patients. These results may provide insight into potential age-specific immunomodulatory targets in COVID-19.