Basal ganglia engagement during REM sleep movements in Parkinson's disease.

Ajay K VermaSergio Francisco Acosta LenisJoshua E AmanDavid Escobar SanabriaJing WangAmy PearsonMeghan HillRemi PatriatLauren E SchrockScott E CooperMichael C ParkNoam HarelMichael J HowellColum D MacKinnonJerrold L VitekLuke A Johnson

Published in: NPJ Parkinson's disease (2022)

To elucidate the role of the basal ganglia during REM sleep movements in Parkinson's disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13-35 Hz) synchronized during REM sleep movements; furthermore, high-frequency oscillations (150-350 Hz) synchronized during movement irrespective of sleep-wake states. Our results demonstrate differential engagement of the basal ganglia during REM sleep and awake movements.

Keyphrases

high frequency
sleep quality
physical activity
end stage renal disease
newly diagnosed
social media
transcranial magnetic stimulation
ejection fraction
deep brain stimulation
prognostic factors
peritoneal dialysis
depressive symptoms