Testosterone deficiency promotes arterial stiffening independent of sex chromosome complement.
Anil SakamuriBruna VisniauskasIsabella Kilanowski-DorohAlexandra B McNallyAriane ImulindeAnne KamauDivya SengottaianJohn McLachlanMontserrat AngueraFranck Mauvais-JarvisSarah H LindseyBernard Ojwang OgolaPublished in: Biology of sex differences (2024)
Testosterone deprivation increases arterial stiffening and vascular wall remodeling. Castration increases Col1α1 in male mice with XX sex chromosome complement. Our study shows decreased aortic contractile genes in castrated mice with XX than XY sex chromosomes.
Keyphrases
- replacement therapy
- copy number
- skeletal muscle
- aortic valve
- left ventricular
- genome wide
- gene expression
- pulmonary artery
- dna methylation
- metabolic syndrome
- high fat diet induced
- coronary artery
- smooth muscle
- adipose tissue
- transcription factor
- pulmonary arterial hypertension
- insulin resistance
- bioinformatics analysis