MicroRNA Let-7 Induces M2 Macrophage Polarization in COPD Emphysema Through the IL-6/STAT3 Pathway.

Tingting LiuZheming ZhangWeiyu ShenYan WuTao Bian

Published in: International journal of chronic obstructive pulmonary disease (2023)

Our results indicate that CS decreased let-7c expression in HBE cells, and M2 AM polarization was dominant in COPD. In HBE cells, let-7c could inhibit M2 polarization of AMs through the IL-6/STAT3 pathway, providing potential diagnostic and therapeutic value for slowing COPD emphysema.

Keyphrases

chronic obstructive pulmonary disease
lung function
induced apoptosis
cell cycle arrest
cell proliferation
cystic fibrosis
air pollution
cell death
risk assessment
endoplasmic reticulum stress
pulmonary fibrosis