Eicosatetraynoic Acid Regulates Pro-Fibrotic Pathways in an Induced Pluripotent Stem Cell Derived Macrophage:Human Intestinal Organoid Model of Crohn's Disease.
Ingrid JurickovaBenjamin W DreskinElizabeth AngermanErin BonkowskiKentaro TominagaKentaro IwasawaTzipi BraunTakanori TakebeMichael A HelmrathYael HabermanJames M WellsLee A DensonPublished in: bioRxiv : the preprint server for biology (2024)
ETYA inhibits pro-fibrotic effects of LPS-primed macrophages upon co-cultured HIO. This model may be used in future untargeted screens for small molecules to treat refractory CD.
Keyphrases
- endothelial cells
- anti inflammatory
- high glucose
- systemic sclerosis
- idiopathic pulmonary fibrosis
- mass spectrometry
- inflammatory response
- adipose tissue
- high throughput
- genome wide
- gene expression
- diabetic rats
- induced pluripotent stem cells
- oxidative stress
- liquid chromatography
- drug induced
- dna methylation
- high resolution mass spectrometry
- nk cells
- simultaneous determination
- tandem mass spectrometry
- gas chromatography