Systematic or Test-Guided Treatment for Tuberculosis in HIV-Infected Adults.

François-Xavier BlancAnani D BadjeMaryline BonnetDelphine GabillardEugène MessouConrad MuzooraSovannarith SamrethBang D NguyenLaurence BorandAnaïs DomergueDelphine RapoudNaome NatukundaSopheak ThaiSylvain JuchetSerge P EholiéStephen D LawnSerge K DomouaXavier AnglaretDidier Laureillardnull null

Published in: The New England journal of medicine (2020)

Among severely immunosuppressed adults with HIV infection who had not previously received ART, systematic treatment for tuberculosis was not superior to test-guided treatment in reducing the rate of death or invasive bacterial disease over 24 or 48 weeks and was associated with more grade 3 or 4 adverse events. (Funded by the Agence Nationale de Recherches sur le Sida et les Hépatites Virales; STATIS ANRS 12290 ClinicalTrials.gov number, NCT02057796.).

Keyphrases

hiv infected
antiretroviral therapy
mycobacterium tuberculosis
hiv aids
adverse drug
drug induced