Epicutaneous Administration of 17β-Estradiol Induces Langerhans Cells Depletion.
Katia Jarquin-YanezMiguel Ángel Herrera-EnriquezCristina LeminiEdith Melendez-MorenoPaulina Villena-LópezMaria Estela ÁvilaBeatriz Hernández-TéllezGabriela Piñón-ZárateEnrique Agustin Sampedro-CarrilloAndrés Eliú Castell-RodríguezPublished in: Immunological investigations (2021)
The topical administration of E2 induced a transitory local diminution of LC population and a tolerogenic phenotype. This decrease in epidermal LC suggests that E2 may affect skin immune responses, inducing an inhibitory response, which should be considered when prescribing topical E2 medications.
Keyphrases
- wound healing
- immune response
- dendritic cells
- induced apoptosis
- simultaneous determination
- primary care
- high glucose
- cell cycle arrest
- regulatory t cells
- mass spectrometry
- liquid chromatography
- endoplasmic reticulum stress
- drug induced
- toll like receptor
- soft tissue
- emergency department
- estrogen receptor
- oxidative stress
- signaling pathway
- endothelial cells
- cell proliferation
- inflammatory response
- high resolution