Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adult C. elegans muscle.

Christopher J GaffneyFreya ShephardJeff ChuDavid L BaillieAnn RoseDumitru Constantin-TeodosiuPaul L GreenhaffNathaniel J Szewczyk

Published in: Journal of cachexia, sarcopenia and muscle (2015)

Constitutive cationic influx into muscle appears to cause caspase degradation of cytosolic proteins as the result of mitochondrial dysfunction, which may be relevant to ageing and sarcopenia.

Keyphrases

skeletal muscle
cell death
induced apoptosis
protein protein
oxidative stress
signaling pathway
endoplasmic reticulum stress
binding protein
childhood cancer