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Single-cell RNA sequencing of mitotic-arrested prospermatogonia with DAZL::GFP chickens and revealing unique epigenetic reprogramming of chickens.

Hyeon Jeong ChoiKyung Min JungDeivendran RengarajKyung Youn LeeEunhui YooTae Hyun KimJae-Yong Han
Published in: Journal of animal science and biotechnology (2022)
We found a unique epigenetic-reprogramming schedule of mitotic-arrested chicken prospermatogonia and prolonged hypomethylation after hatching. This will provide a foundation for understanding the process of germ-cell epigenetic regulation in several species for which this process is not clearly described. Our findings on the biological processes related to sex-specific differentiation of prospermatogonia could help studying germline development in vitro more elaborately.
Keyphrases
  • single cell
  • germ cell
  • dna methylation
  • rna seq
  • cell cycle
  • heat stress
  • gene expression
  • high throughput
  • disease virus
  • dna repair
  • cell proliferation