Pregnane X receptor activation constrains mucosal NF-κB activity in active inflammatory bowel disease.

J Jasper DeuringMeng LiWanlu CaoSunrui ChenWenshi WangColin de HaarC Janneke van der WoudeMaikel Petrus Peppelenbosch

Published in: PloS one (2019)

Our data indicate that the PXR is a major and clinically relevant antagonist of NF-κB activity in the intestinal epithelial compartment during inflammatory bowel disease.

Keyphrases

signaling pathway
lps induced
ulcerative colitis
pi k akt
oxidative stress
nuclear factor
electronic health record
big data
cell proliferation