Antenatal screening for fetal trisomies using microarray-based cell-free DNA testing: A systematic review and meta-analysis.

Julia GeppertChris StintonSamantha JohnsonAileen ClarkeDimitris GrammatopoulosSian Taylor-Phillips

Published in: Prenatal diagnosis (2019)

Included studies suggest that NIPT using microarray-based cfDNA testing has high sensitivity and specificity for detecting fetal trisomy 21, 18, and 13. However, the evidence base is small and at high risk of bias.

Keyphrases

pregnant women
preterm birth
bioinformatics analysis
structural basis