Beneficial Effects of Tacrolimus on Brain-Death-Associated Right Ventricular Dysfunction in Pigs.

Asmae BelhajLaurence DewachterAstrid MonierGregory VeghSandrine RoriveMyriam RemmelinkMélanie Closset Christian MélotJacques CreteurIsabelle SalmonBenoît Rondelet

Published in: International journal of molecular sciences (2023)

Brain death was associated with isolated RV dysfunction. Tacrolimus prevented RV dysfunction induced by BD through the inhibition of apoptosis and inflammation activation.

Keyphrases

oxidative stress
mycobacterium tuberculosis
resting state
white matter
functional connectivity
cell death
cell cycle arrest
cell proliferation
signaling pathway
brain injury
blood brain barrier