Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer.

Precious Takondwa MakondiChi-Ming ChuPo-Li WeiYu-Jia Chang

Published in: PloS one (2017)

Targeting the MAPK signal transduction pathway through the targeting of the FGF2, FGF9, MECOM, PLA2G4C and PRKACB might increase tumor responsiveness to irinotecan treatment.

Keyphrases

cancer therapy
signaling pathway
genome wide
oxidative stress
drug delivery
pi k akt
combination therapy
bioinformatics analysis
genome wide identification