Preparation of [ 18 F]Alkenyl Fluorides Using No-Carrier-Added [ 18 F]AgF via Silver-Mediated Direct Radiofluorination of Alkynes.

We have developed a versatile method for the radiosynthesis of [ 18 F]alkenyl fluorides using no-carrier-added [ 18 F]AgF via the silver-mediated direct radiofluorination of alkynes. A variety of electron-deficient internal alkynes were compatible with this strategy and gave the desired product in good regioselectivity and RCY. This method could also be applied to the late-stage radiofluorination and showed potential in nuclear medicine development.