Is GBA1 T369M not a risk factor for Parkinson's disease in the Swedish population?

Kajsa Atterling Brolin David Bäckström Joel Wallenius Ziv Gan Or Andreas Puschmann Oskar Hansson Maria Swanberg

Published in: medRxiv : the preprint server for health sciences (2024)

Variants in GBA1 are important genetic risk factors in Parkinson's disease (PD). GBA1 T369M has been linked to an ∼80% increased PD risk but the reports are conflicting and the relevance of GBA1 variants in different populations varies. A lack of association between T369M and PD in the Swedish population was recently reported but needs further validation. We therefore investigated T369M in 1,808 PD patients and 2,183 controls and our results support that T369M is not a risk factor for PD in the Swedish population.

Keyphrases

risk factors
copy number
end stage renal disease
ejection fraction
newly diagnosed
emergency department
peritoneal dialysis
dna methylation
patient reported outcomes
adverse drug