Direct C-H Carboxylation Forming Polyfunctionalized Aromatic Carboxylic Acids by Combined Brønsted Bases.

Masanori ShigenoKazuya HanasakaItsuki ToharaKoki IzumiHiroyuki YamakoshiEunsang KwonKanako Nozawa-KumadaYoshinori Kondo

Published in: Organic letters (2022)

CO 2 fixation into electron-deficient aromatic C-H bonds proceeds with the combined Brønsted bases LiO- t -Bu and LiO- t -Am/CsF/18-crown-6 ( t -Am = CEtMe 2 ) under a CO 2 atmosphere to afford a variety of polyfunctionalized aromatic carboxylic acids.

Keyphrases

amino acid
minimally invasive