Combined Treatment with a WNT Inhibitor and the NSAID Sulindac Reduces Colon Adenoma Burden in Mice with Truncated APC.

Maree C FauxJanet WeinstockSophia GogosEmma PratoAlexander I AzimpourRyan O'KeefeYasmin Cathcart-KingAlexandra L GarnhamMatthias ErnstAdele PreaudetMichael ChristieTracy L PutoczkiMichael BuchertAntony W Burgess

Published in: Cancer research communications (2022)

-mutant colon adenoma cells and suggests a strategy for colorectal cancer prevention and new treatments for patients with advanced colorectal cancer.

Keyphrases

induced apoptosis
cell cycle arrest
stem cells
cell proliferation
wild type
high fat diet induced
type diabetes
endoplasmic reticulum stress
oxidative stress
metabolic syndrome
signaling pathway
skeletal muscle
replacement therapy
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