Transient receptor potential vanilloid 4 channels are important regulators of parenchymal arteriole dilation and cognitive function.
Janice M Diaz-OteroTing-Chieh YenAmna AhmadErinn Laimon-ThomsonBana AbolibdehKara KellyMatthew T LewisRobert W WisemanWilliam F JacksonAnne M DorrancePublished in: Microcirculation (New York, N.Y. : 1994) (2019)
Our data indicate that TRPV4 channels play a critical role in cerebral perfusion, PA dilation, cognition, and inflammation. Impaired TRPV4 function in diseases such as hypertension may increase the risk of the development of vascular dementia.
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