Beneficial Effects of Eruca sativa Defatted Seed Meal on Visceral Pain and Intestinal Damage Resulting from Colitis in Rats.
Elena LucariniLaura MicheliEleonora PagnottaRoberto MatteoCarmen ParisioAlessandra TotiValentina FerraraClara CiampiAlma MartelliLara TestaiVincenzo CalderoneMichele SavinoMario RussoNicola PecchioniCarla GhelardiniLorenzo Di Cesare MannelliPublished in: Foods (Basel, Switzerland) (2022)
Most therapies used in patients affected by inflammatory bowel diseases are ineffective in preventing the development of chronic visceral hypersensitivity, mainly due to inflammation-induced enteric neuroplasticity. Glucosinolates, secondary metabolites mainly of Brassicaceae with anti-inflammatory and neuroprotective properties, are effective in treating both neuropathic and arthritis pain through H 2 S release and Kv7 potassium channel activation. The aim of this work was to investigate the protective and anti-hyperalgesic efficacy of a defatted seed meal from Eruca sativa Mill. (Brassicaceae), rich in glucosinolates, in a rat model of colitis induced by 2,4-dinitrobenzene sulfonic acid (DNBS). The mechanisms of action were also investigated. Visceral pain was assessed by measuring the abdominal response to colorectal distension. Fifteen days after colitis induction, the acute administration of E. sativa defatted seed meal (0.1-1 g kg - 1 p.o.) dose-dependently relieved pain. This effect was hampered by co-administering an H 2 S scavenger or a selective Kv7 blocker. Administering E. sativa (1 g kg -1 ) for 14 days, starting after DNBS injection, contributed to counteracting visceral pain persistence in the post-inflammatory phase of colitis by promoting colon healing from the damage and reducing enteric gliosis. E. sativa defatted seed meal might be employed as a nutraceutical tool for supporting abdominal pain relief in patients.
Keyphrases
- chronic pain
- end stage renal disease
- pain management
- neuropathic pain
- oxidative stress
- ejection fraction
- newly diagnosed
- chronic kidney disease
- drug induced
- insulin resistance
- peritoneal dialysis
- prognostic factors
- anti inflammatory
- rheumatoid arthritis
- magnetic resonance imaging
- ulcerative colitis
- type diabetes
- spinal cord
- liver failure
- metabolic syndrome
- magnetic resonance
- intensive care unit
- spinal cord injury
- mass spectrometry
- brain injury
- respiratory failure
- single molecule
- postoperative pain
- blood brain barrier
- stress induced
- patient reported
- angiotensin converting enzyme
- dual energy