Long-term lung inflammation is reduced by estradiol treatment in brain dead female rats.
Fernanda Yamamoto Ricardo-da-SilvaRoberto ArmstrongMarina Vidal Dos SantosCristiano de Jesus CorreiaRaphael Dos Santos Coutinho E SilvaLucas Ferreira da AnunciaçãoLuiz Felipe Pinho MoreiraHendrik Gerrit Derk LeuveninkAna Cristina Breithaupt-FaloppaPublished in: Clinics (Sao Paulo, Brazil) (2021)
Brain death-induced lung inflammation in females is modulated by estradiol treatment. Study data suggest that estradiol can control the inflammatory response by modulating the release of mediators after brain death in the long term. These results strengthen the idea of estradiol as a therapy for donor lungs and improving transplant outcomes.