Elucidation of Tumor-Stromal Heterogeneity and the Ligand-Receptor Interactome by Single-Cell Transcriptomics in Real-world Pancreatic Cancer Biopsies.
Jaewon J LeeVincent BernardAlexander SemaanMaria E MonbergJonathan HuangBret M StephensDaniel LinKimal I RajapaksheBrian R WestonManoop S BhutaniCara L HaymakerChantale BernatchezCullen M TaniguchiAnirban MaitraPaola A GuerreroPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Our analysis demonstrates that the use of de novo biopsies from patients with PDAC paired with scRNA-seq may facilitate therapeutic prediction from limited biopsy samples.