Association between COPD exacerbations and lung function decline during maintenance therapy.

Marjan KerkhofJaco VoorhamPaul DorinskyClaudia CabreraPatrick DarkenJanwillem Wh KocksJ Mark FitzGeraldDon D SinVictoria CarterDavid J Price

Published in: Thorax (2020)

Exacerbations are associated with a more rapid loss of lung function among COPD patients with elevated blood eosinophils, defined as ≥350 cells/µL, not treated with ICS. More aggressive prevention of exacerbations using ICS in such patients may prevent excess loss of lung function.

Keyphrases

lung function
chronic obstructive pulmonary disease
cystic fibrosis
air pollution
end stage renal disease
newly diagnosed
ejection fraction
induced apoptosis
prognostic factors
peritoneal dialysis
stem cells
patient reported outcomes
signaling pathway
cell cycle arrest
sensitive detection