Multigene Panel Testing Yields High Rates of Clinically Actionable Variants Among Patients With Colorectal Cancer.

Sarah E Coughlin Brandie H LeachDana Farengo ClarkSarah M Nielsen Kathryn E Hatchell Edward D Esplin Bryson W Katona

Published in: JCO precision oncology (2022)

To our knowledge, this is the largest study to date examining MGPT in CRC, demonstrating high rates of clinically actionable variants detected across all age groups, panel sizes, and racial/ethnic groups. This work supports consideration of broadening germline genetic testing criteria for individuals with CRC.

Keyphrases

copy number
gene expression
oxidative stress