A novel inhibitor of ADAM17 sensitizes colorectal cancer cells to 5-Fluorouracil by reversing Notch and epithelial-mesenchymal transition in vitro and in vivo.

Dan-Dan LiChang-Hao ZhaoHuai-Wei DingQiong WuTian-Shu RenJian WangCong-Qin ChenQing-Chun Zhao

Published in: Cell proliferation (2018)

A novel ADAM17 inhibitor ZLDI-8 may be a potential chemosensitizer which sensitized CRC cells to 5-fluorouracil or irinotecan by reversing Notch and EMT pathways.

Keyphrases

epithelial mesenchymal transition
induced apoptosis
signaling pathway
transforming growth factor
endoplasmic reticulum stress
cell proliferation
cell cycle arrest
oxidative stress
pi k akt
human health