Detecting multiple differentially methylated CpG sites and regions related to dimensional psychopathology in youths.

Leticia M SpindolaMarcos L SantoroPedro M PanVanessa K OtaGabriela XavierCarolina M CarvalhoFernanda TalaricoPatrick SleimanMichael MarchRenata PellegrinoElisa BrietzkeRodrigo Grassi-OliveiraJair J MariAry GadelhaEuripedes C MiguelLuis A RohdeRodrigo A BressanDiego R MazzottiJoão R SatoGiovanni A SalumHakon HakonarsonSintia Nogueira Belangero

Published in: Clinical epigenetics (2019)

We observed that changes in DNA methylation and, consequently, in gene expression in the peripheral blood occurred concurrently with the emergence of dimensional psychopathology in youths. Therefore, epigenomic modulations might be involved in the regulation of an individual's development of psychopathology.

Keyphrases

dna methylation
gene expression
peripheral blood
anorexia nervosa
genome wide
drug induced