Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.
Iris PostmusHelen R WarrenStella TrompetBenoit J ArsenaultChristy L AveryJoshua C BisDaniel I ChasmanCatherine E de KeyserHarshal A DeshmukhDaniel S EvansQiPing FengXiaohui LiRoelof A J SmitAlbert V SmithFangui SunKent D TaylorAlice M ArnoldMichael R BarnesBryan J BarrattJohn BetteridgeS Matthijs BoekholdtEric BoerwinkleBrendan M BuckleyY-D Ida ChenAnton J M de CraenSteven R CummingsJoshua C DennyMarie Pierre DubéPaul N DurringtonGudny EiriksdottirIan FordXiuqing GuoTamara B HarrisSusan R HeckbertAlbert HofmanG Kees HovinghJohn J P KasteleinLeonore J LaunerChing-Ti LiuYongmei LiuThomas LumleyPaul M McKeiguePatricia B MunroeAndrew NeilDeborah A NickersonFredrik NybergEoin O'BrienChristopher J O'DonnellWendy PostNeil PoulterRamachandran S VasanKenneth RiceStephen S RichFernando RivadeneiraNaveed SattarPeter SeverSue Shaw-HawkinsDenis C ShieldsP Eline SlagboomNicholas L SmithJoshua D SmithNona SotoodehniaAlice StantonDavid J StottBruno H StrickerTil StürmerAndré G UitterlindenWei-Qi WeiRudi G J WestendorpEric A WhitselKerri L WigginsRussell A WilkeChristie M BallantyneHelen M ColhounL Adrienne CupplesOscar H FrancoVilmundur GudnasonGraham HitmanColin N A PalmerBruce M PsatyPaul M RidkerJeanette M StaffordCharles M SteinJean-Claude TardifMark J CaulfieldJ Wouter JukemaJerome I RotterRonald M KraussPublished in: Journal of medical genetics (2016)
Based on results from this study that included a relatively large sample size, we suggest that CETP may be the only detectable locus with common genetic variants that influence HDL-C response to statins substantially in individuals of European descent. Although CETP is known to be associated with HDL-C, we provide evidence that this pharmacogenetic effect is independent of its association with baseline HDL-C levels.