Pharmacological blockade of the P2X7 receptor reverses retinal damage in a rat model of type 1 diabetes.

Carmen ClappNundehui Diaz-LezamaElva Adan-CastroGabriela Ramirez-HernandezBibiana Moreno-CarranzaAlba Clara SartiSimonetta FalzoniAnna SoliniFrancesco Di Virgilio

Published in: Acta diabetologica (2019)

P2X7R blockade might be promising strategy for the treatment of microvascular changes observed in the early phases of diabetic retinopathy.

Keyphrases

diabetic retinopathy
optical coherence tomography
type diabetes
oxidative stress
cardiovascular disease
adipose tissue
insulin resistance
binding protein
weight loss
replacement therapy