Circle-Seq reveals genomic and disease-specific hallmarks in urinary cell-free extrachromosomal circular DNAs.
Wei LvXiaoguang PanPeng HanZiyu WangWeijia FengXue XingQingqing WangKunli QuYuchen ZengCailin ZhangZhe XuYi LiTianyu ZhengLing LinChengxun LiuXuemei LiuHanbo LiRasmus Amund HenriksenLars BolundLin LinXin JinHuanming YangXiuqing ZhangTailang YinBirgitte RegenbergFan HeYonglun LuoPublished in: Clinical and translational medicine (2022)
This work discovers and provides the first deep characterisation of ucf-eccDNAs and suggests ucf-eccDNA as a valuable noninnvasive biomarker for urogenital disorder diagnosis and monitoring.