Mesenchymal stromal cells ameliorate diabetes-induced muscle atrophy through exosomes by enhancing AMPK/ULK1-mediated autophagy.

Jia SongJidong LiuChen CuiHuiqing HuNan ZangMengmeng YangJingwen YangYing ZouJinquan LiLingshu WangQin HeXinghong GuoRuxing ZhaoFei YanFuqiang LiuXinguo HouZheng SunLi Chen

Published in: Journal of cachexia, sarcopenia and muscle (2023)

Our results suggest that human umbilical cord mesenchymal stromal cells mitigate diabetes- and obesity-induced muscle atrophy via enhancing AMPK/ULK1-mediated autophagy through exosomes, with implications of applying hucMSCs or hucMSC-derived exosomes to treat muscle atrophy.

Keyphrases

mesenchymal stem cells
umbilical cord
skeletal muscle
type diabetes
bone marrow
high glucose
stem cells
endothelial cells
cardiovascular disease
cell death
insulin resistance
diabetic rats
endoplasmic reticulum stress
glycemic control
metabolic syndrome
signaling pathway
weight loss
drug induced
protein kinase