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Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating.

Yang ZhuKaicheng DengJianwei ZhouChong LaiZuwei MaHua ZhangJiazhen PanLiyin ShenMatthew D BucknorEugene OzhinskySeungil KimGuangjie ChenSang-Ho YeYue ZhangDonghong LiuChangyou GaoYonghua XuHuanan WangWilliam R Wagner
Published in: Nature communications (2024)
Shape-memory materials hold great potential to impart medical devices with functionalities useful during implantation, locomotion, drug delivery, and removal. However, their clinical translation is limited by a lack of non-invasive and precise methods to trigger and control the shape recovery, especially for devices implanted in deep tissues. In this study, the application of image-guided high-intensity focused ultrasound (HIFU) heating is tested. Magnetic resonance-guided HIFU triggered shape-recovery of a device made of polyurethane urea while monitoring its temperature by magnetic resonance thermometry. Deformation of the polyurethane urea in a live canine bladder (5 cm deep) is achieved with 8 seconds of ultrasound-guided HIFU with millimeter resolution energy focus. Tissue sections show no hyperthermic tissue injury. A conceptual application in ureteral stent shape-recovery reduces removal resistance. In conclusion, image-guided HIFU demonstrates deep energy penetration, safety and speed.
Keyphrases
  • high intensity
  • magnetic resonance
  • resistance training
  • drug delivery
  • ultrasound guided
  • spinal cord injury
  • magnetic resonance imaging
  • gene expression
  • risk assessment
  • contrast enhanced
  • editorial comment