A Review of Genetic Polymorphisms and Susceptibilities to Complications after Aneurysmal Subarachnoid Hemorrhage.
José A Medina-SuárezFrancisco Rodríguez-EsparragónCoralia Sosa-PérezSara Cazorla-RiveroLaura B Torres-MataAruma Jiménez-O'ShanahanBernardino Clavo VarasJesús Morera-MolinaPublished in: International journal of molecular sciences (2022)
Delayed cerebral ischemia (DCI) and vasospasm are two complications of subarachnoid hemorrhages (SAHs) which entail high risks of morbidity and mortality. However, it is unknown why only some patients who suffer SAHs will experience DCI and vasospasm. The purpose of this review is to describe the main genetic single nucleotide polymorphisms (SNPs) that have demonstrated a relationship with these complications. The SNP of the nitric oxide endothelial synthase (eNOS) has been related to the size and rupture of an aneurysm, as well as to DCI, vasospasm, and poor neurological outcome. The SNPs responsible for the asymmetric dimetilarginine and the high-mobility group box 1 have also been associated with DCI. An association between vasospasm and the SNPs of the eNOS, the haptoglobin, and the endothelin-1 receptor has been found. The SNPs of the angiotensin-converting enzyme have been related to DCI and poor neurological outcome. Studies on the SNPs of the Ryanodine Receptor yielded varying results regarding their association with vasospasm.
Keyphrases
- subarachnoid hemorrhage
- cerebral ischemia
- genome wide
- brain injury
- dna methylation
- nitric oxide
- angiotensin converting enzyme
- nitric oxide synthase
- genome wide association
- endothelial cells
- blood brain barrier
- angiotensin ii
- risk factors
- copy number
- pi k akt
- binding protein
- coronary artery
- risk assessment
- genetic diversity
- solid state
- cell proliferation