Nomination of a novel plasma protein biomarker panel capable of classifying Alzheimer's disease dementia with high accuracy in an African American cohort.
Lindsey A KuchenbeckerKevin J ThompsonCheyenne D HurstBianca M OpdenboschMichael G HeckmanJoseph S ReddyThuy NguyenHeidi L CasellasKatie D SoteloDelila J ReddyJohn A LucasGregory S DayFloyd B WillisNeill R Graff-RadfordNilufer Ertekin-TanerKrishna R KalariMinerva M CarrasquilloPublished in: bioRxiv : the preprint server for biology (2024)
This study demonstrates the potential of biomarker discovery through untargeted plasma proteomics and machine learning approaches. Our findings also highlight the potential importance of the matrisome and cerebrovascular dysfunction in AD pathophysiology.