Endothelial deletion of PKCδ prevents VEGF inhibition and restores blood flow reperfusion in diabetic ischemic limb.
Laura CroteauClément MercierÉtienne Fafard-CoutureAlexandre NadeauStéphanie RobillardValérie BretonAndréanne GuayFarah LizotteMarc-Antoine DespatisPedro GeraldesPublished in: Diabetes & vascular disease research (2021)
Our data provide new highlights in mechanisms by which PKCδ activation in EC contributed to poor collateral vessel formation, thus, offering novel therapeutic targets to improve angiogenesis in the diabetic limb.
Keyphrases
- blood flow
- endothelial cells
- wound healing
- vascular endothelial growth factor
- type diabetes
- cerebral ischemia
- acute myocardial infarction
- electronic health record
- big data
- protein kinase
- acute ischemic stroke
- ischemia reperfusion injury
- brain injury
- blood brain barrier
- artificial intelligence
- acute coronary syndrome
- machine learning
- percutaneous coronary intervention
- atrial fibrillation