Comprehensive SPECT/CT system characterization and calibration for 177Lu quantitative SPECT (QSPECT) with dead-time correction.
Andrea FrezzaCorentin DesportCarlos UribeWei ZhaoAnna CellerPhilippe DesprésJean-Mathieu BeauregardPublished in: EJNMMI physics (2020)
Serial planar acquisitions of sources in air using an activity range covering the full operational capacity of the SPECT/CT system, with multiple energy windows for wide-spectrum count rate monitoring, and followed by simultaneous determination of CF and τ using a single equation derived from the paralysable model, constitutes a practical method to enable accurate dead-time-corrected QSPECT imaging in a post-177Lu radionuclide therapy setting.
Keyphrases
- simultaneous determination
- high resolution
- pet ct
- liquid chromatography tandem mass spectrometry
- image quality
- dual energy
- computed tomography
- tandem mass spectrometry
- contrast enhanced
- high performance liquid chromatography
- positron emission tomography
- cystic fibrosis
- ultra high performance liquid chromatography
- liquid chromatography
- solid phase extraction
- drinking water
- peripheral blood
- magnetic resonance
- mass spectrometry
- stem cells
- low cost
- mesenchymal stem cells
- fluorescence imaging
- gas chromatography