A clinical-pathogenetic approach on associated anomalies and chromosomal defects supports novel candidate critical regions and genes for gastroschisis.
Víctor M Salinas-TorresRafael A Salinas-TorresRicardo M Cerda-FloresHugo L Gallardo-BlancoLaura E Martínez-de-VillarrealPublished in: Pediatric surgery international (2018)
Our findings suggest that gastroschisis may result from the interaction of several chromosomal regions in an additive manner as a pool of candidate genes were identified from critical regions supporting a role for vascular disruption, thrombosis, and mesodermal deficiency in the pathogenesis of gastroschisis.