MicroRNA-206 promotes the recruitment of CD8+ T cells by driving M1 polarisation of Kupffer cells.

Ningning LiuXiaomei WangClifford John SteerGuisheng Song

Published in: Gut (2021)

M2 polarisation of KCs is a major contributor of HCC in AKT/Ras mice. MicroRNA-206, by driving M1 polarisation of KCs, promoted the recruitment of CD8+ T cells and prevented HCC, suggesting its potential use as an immunotherapeutic approach.

Keyphrases

induced apoptosis
signaling pathway
cell cycle arrest
wild type
cell proliferation
type diabetes
cell death
pi k akt
skeletal muscle