Assessment of Orbital Computed Tomography (CT) Imaging Biomarkers in Patients with Thyroid Eye Disease.
Shikha ChagantiKevin MundyMichael P DeLisiKatrina M NelsonRobert L HarriganRobert L GallowayBennett A LandmanLouise A MawnPublished in: Journal of digital imaging (2021)
To understand potential orbital biomarkers generated from computed tomography (CT) imaging in patients with thyroid eye disease. This is a retrospective cohort study. From a database of an ongoing thyroid eye disease research study at our institution, we identified 85 subjects who had both clinical examination and laboratory records supporting the diagnosis of thyroid eye disease and concurrent imaging prior to any medical or surgical intervention. Patients were excluded if imaging quality or type was not amenable to segmentation. The images of 170 orbits were analyzed with the developed automated segmentation tool. The main outcome measure was to cross 25 CT structural metrics for each eye with nine clinical markers using a Kendall rank correlation test to identify significant relationships. The Kendall rank correlation test between automatically calculated CT metrics and clinical data demonstrated numerous correlations. Extraocular rectus muscle metrics, such as the average diameter of the superior, medial, and lateral rectus muscles, showed a strong correlation (p < 0.05) with loss of visual acuity and presence of ocular motility defects. Hertel measurements demonstrated a strong correlation (p < 0.05) with volumetric measurements of the optic nerve and other orbital metrics such as the crowding index and proptosis. Optic neuropathy was strongly correlated (p < 0.05) with an increase in the maximum diameter of the superior muscle. This novel method of automated imaging metrics may provide objective, rapid clinical information. This data may be useful for appreciation of severity of thyroid eye disease and recognition of risk factors of visual impairment from dysthyroid optic neuropathy from CT imaging.
Keyphrases
- computed tomography
- high resolution
- dual energy
- image quality
- positron emission tomography
- optic nerve
- contrast enhanced
- risk factors
- end stage renal disease
- high throughput
- emergency department
- magnetic resonance imaging
- machine learning
- skeletal muscle
- chronic kidney disease
- healthcare
- magnetic resonance
- peritoneal dialysis
- newly diagnosed
- optical coherence tomography
- artificial intelligence
- big data
- radiation therapy
- mass spectrometry
- sensitive detection
- fluorescence imaging
- patient reported outcomes
- climate change
- risk assessment
- photodynamic therapy
- quality improvement
- rectal cancer