Diacylglycerol kinase delta overexpression improves glucose clearance and protects against the development of obesity.
Maxence JolletFlavia TramontanaLake Q JiangMelissa L BorgMladen SavikjMichael S KuefnerJulie MassartThais de Castro BarbosaLouise Mannerås-HolmAntonio ChecaNicolas J PillonAlexander V ChibalinMarie BjörnholmJuleen R ZierathPublished in: Metabolism: clinical and experimental (2024)
Overexpression of DGKδ induces adaptive changes in both skeletal muscle and adipose tissue, resulting in protection against HFD-induced obesity. DGKδ overexpression recapitulates exercise-induced adaptations on energy homeostasis and skeletal muscle gene expression profiles.
Keyphrases
- insulin resistance
- skeletal muscle
- adipose tissue
- high fat diet
- cell proliferation
- high fat diet induced
- metabolic syndrome
- transcription factor
- type diabetes
- weight loss
- high glucose
- genome wide
- diabetic rats
- copy number
- physical activity
- drug induced
- glycemic control
- high intensity
- protein kinase
- body mass index
- blood pressure