Epigenetic Silencing of Tumor Suppressor miR-124 Directly Supports STAT3 Activation in Cutaneous T-Cell Lymphoma.
Lidia García-ColmeneroJéssica GonzálezJuan SandovalYolanda GuillénAngel Diaz-LagaresEvelyn AndradesArnau IglesiasLara NonellRamon Maria PujolAnna BigasLluís EspinosaFernando GallardoPublished in: Cells (2020)
Our study highlights the importance of the miR-124/STAT3 axis in CTCL and demonstrates that the STAT3 pathway is regulated through epigenetic mechanisms in these cells. Since deregulated STAT3 signaling has a major impact on CTCL initiation and progression, a better understanding of the molecular basis of the miR-124/STAT3 axis may provide useful information for future personalized therapies.