Aryl Hydrocarbon Receptor Knockout Accelerates PanIN Formation and Fibro-Inflammation in a Mutant Kras -Driven Pancreatic Cancer Model.
Morgan T WalcheckPatrick B SchwartzNoah D CarrilloKristina A MatkowskyjManabu NukayaChristopher A BradfieldSean M Ronnekleiv-Kelly
Published in: Pancreas (2024)
These findings show the loss of AHR results in heightened Kras -induced PanIN formation, through modulation of immune cells within the pancreatic tumor microenvironment.