Faecal Microbiota Transplantation Engraftment After Budesonide or Placebo in Patients With Active Ulcerative Colitis Using Pre-selected Donors: A Randomized Pilot Study.
Emilie van LingenSam NooijElisabeth M TerveerEmily CrossetteAmanda L PrinceShakti K BhattaraiAndrea WatsonGianluca GalazzoRajita MenonRose L SzabadyVanni BucciJason M NormanC Janneke van der WoudeSander van der MarelHein W VerspagetAndrea E van der Meulen-de JongJosbert J KellerPublished in: Journal of Crohn's & colitis (2024)
In this small study, pretreatment with budesonide did not significantly influence engraftment or clinical response after FMT. However, clinical response appeared to be donor-dependent. Response to FMT may be related to transfer of specific strains instead of overall engraftment, demonstrating the need to characterize mechanisms of actions of strains that maximize therapeutic benefit in UC.