Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma.
Mekenzie M PeshoffPravesh GuptaShivangi OberaiRakesh TrivediHiroshi KatayamaPrashanth ChakrapaniMinghao DangSimona MigliozziJoy GuminDivya B KadriJessica K LinNancy K MilamMark E MaynardBrian D VaillantBrittany Parker-KerriganFrederick F LangJason T HuseAntonio IavaroneLinghua WangKaren Clise-DwyerKrishna P BhatPublished in: Neuro-oncology (2024)
These results indicate that TREM2 is not associated with immunosuppression in gliomas. Instead, TREM2 is an important regulator of phagocytosis that may be exploited as a potential therapeutic strategy for brain tumors.