Knee Alignment Correction by High Tibial Osteotomy Reduces Symptoms and Synovial Inflammation in Knee Osteoarthritis Accompanied by Macrophage Phenotypic Change From M1 to M2.
Shigeo YoshidaKohei NishitaniHiroyuki YoshitomiShinichi KuriyamaShinichiro NakamuraTakayuki FujiiMotoo SaitoYu KoboriAkinori MurakamiKoichi MurataHiromu ItoHideki UenoShuichi MatsudaPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
Correction of lower limb alignment with HTO attenuated synovial inflammation and changed macrophage polarization from M1 to M2, suggesting an improved intraarticular environment in knee OA.