A Study on the Behavior of Smart Starch- co -poly( N -isopropylacrylamide) Hybrid Microgels for Encapsulation of Methylene Blue.
Andresa da Costa RibeiroTania T TominagaTaiana G Moretti BonadioNádya Pesce da SilveiraDaiani C LeitePublished in: ACS omega (2024)
Hybrid microgels made from starch nanoparticles (SNPs) and poly( N -isopropylacrylamide) p(NIPAM) were used as promising hosts for the methylene blue (MB) dye. In this paper, these thermoresponsive microgels were characterized by dynamic light scattering (DLS), zeta potential measurements (ZP), and scanning electron microscopy (SEM) and evaluated as carriers for skin-targeted drug delivery. The hybrid microgel-MB systems in PBS solution were also studied by UV-vis spectroscopy and DLS, revealing discernible differences in spectral intensity and absorption shifts compared to microgels devoid of MB. This underscores the successful integration of methylene blue within the SNPs- co -p(NIPAM) microgels, signifying their potential as efficacious drug delivery vehicles.
Keyphrases
- drug delivery
- electron microscopy
- cancer therapy
- genome wide
- high resolution
- human health
- gene expression
- single molecule
- risk assessment
- high intensity
- optical coherence tomography
- dna methylation
- magnetic resonance imaging
- mass spectrometry
- magnetic resonance
- solid state
- drug release
- genome wide association
- aqueous solution